Ho utloisisa Narrowband UVB Phototherapy

Phekolo e khethehileng bakeng sa psoriasis, vitiligo le eczema

Narrowband UVB Phototherapy - The Basics

"Narrowband" UVB e fetohile phototherapy t hobane e fana ka boholo bo boholo ba maqhubu a molemo ka ho fetisisa a lebone la UV, ha e ntse e fokotsa maqhubu a kotsi a ka bang kotsi. 

E tloaelehileng "Broadband" Mabone a UVB a ntša khanya ka mefuta e mengata e pharalletseng holim'a mahlaseli a UVB, ho kenyeletsoa le maqhubu a kalafo a khethehileng a kalafo ea mafu a letlalo, hammoho le maqhubu a makhutšoane a ikarabellang bakeng sa ho chesoa ke letsatsi (erythema). Ho chesoa ke letsatsi ho na le molemo o mobe oa phekolo, ho eketsa kotsi ea kankere ea letlalo, ho baka ho se phutholohe ha mokuli, 'me ho fokotsa boholo ba UVB ea phekolo e ka nkoang.  

"Narrowband" Ka lehlakoreng le leng, mabone a UVB a ntša khanya holim'a mefuta e khuts'oane haholo ea maqhubu a matla a lekanyelitsoeng sebakeng sa phekolo 'me a sa chesoe ke letsatsi, a sebelisa "sebaka se monate" pakeng tsa tse peli tse ka bang 311 nm. Ka hona, UVB-Narrowband ha ho nahanoa hore e bolokehile ebile e sebetsa hantle ho feta UVB-Broadband, empa e hloka nako e telele ea kalafo kapa lisebelisoa tse nang le li-bulbs tse ngata ho fihlela tekanyo e phahameng, e leng ha ho qala ho ba bofubelu bo bobebe ka mor'a kalafo, e tsejoang ka "sub-erythema" . Mefuta ea UVB-Narrowband ea Solarc e na le sekoaelo sa "UVB-NB" nomorong ea mohlala, joalo ka 1780UVB-NB. Mefuta ea UVB-Broadband ea Solarc e na le sehokelo sa "UVB" feela, joalo ka 1740UVB. "Narrowband UVB" e ntlafalitsoe ke Philips Lighting ea Holland hape e tsejoa e le: Narrow Band UVB, UVB Narrowband, UVB‑NB, NB‑UVB, TL/01, TL-01, TL01, 311 nm, joalo-joalo, (moo "01" ke khoutu ea phosphor ea Philips e kentsoeng linomorong tsa karolo ea bulb ea UVB-Narrowband).

Mme bakeng sa tlhaloso e qaqileng haholoanyane: 

Ho utloisisa Narrowband UVB Phototherapy

"Narrowband" UVB (UVB-NB) e fetohile phekolo ea phototherapy ea khetho bakeng sa psoriasis, vitiligo, atopic dermatitis (eczema), le mafu a mang a letlalo a arabelang lifoto. Ho utloisisa melemo ea "Narrowband" UVB khahlanong le "Broadband" UVB phototherapy e tloaelehileng e hloka kutloisiso ea leseli le mekhoa eo e e amang.

Maqhubu a mahlaseli a mahlo (leseli) a entsoe ka bolelele bo fapaneng ba maqhubu a "leseli" ho tloha ho 100 nanometers (nm) sebakeng sa ultraviolet (UV) ho ea ho 1 millimeter (mm) sebakeng sa infrared (IR). Khanya e bonahalang e tloha ho hoo e ka bang 380 nm (violet) ho ea ho 780 nm (e khubelu) 'me e tsejoa e le "mebala" eo re e bonang ka mahlo. Ultraviolet ha e bonahale ebile e tloha ho 380 nm ho ea ho 100 nm, 'me e arotsoe hape ka UVA (315-380 nm), UVB (280-315 nm), le UVC (100-280 nm).

SETLHOPHA A e bontša matla a lekanyelitsoeng a “leseli” la tlhaho le fihlang holim’a lefatše ka mor’a ho sefa ke sepakapaka sa lefatše. Batho ba fetohile ba pepesehetse maqhubu ana 'ohle, kahoo letlalo la rona le na le likarabo tsa ho sebelisa leseli ka mokhoa o molemo (Vitamin D) le ho re sireletsa ho pepesehela ho feteletseng (ho ba le letlalo la lefutso le ho fifala ha letlalo). "UVB Narrowband" e totobatsoa ho 311 nm 'me e hlaha ka tlhaho khanyeng ea letsatsi, empa eseng ka bongata. Sepakapaka sa lefatše se sefa hoo e ka bang khanya eohle e ka tlaase ho 300 nm.
ho utloisisa narrowband uvb phototherapy
narrawband uvb phototherapy

Maqhubu a fapaneng a "leseli" a hlahisa liphello tse fapaneng ho lisebelisoa. Mekhoa e mengata ea bohlokoa e 'nile ea ithutoa ka saense ho fumana monehelo o lekanyelitsoeng oa wavelength e' ngoe le e 'ngoe ts'ebetsong e ithutoang. Kerafo e tsejoang e le "action spectrum" e sebelisoa ho hlalosa likamano tsena. Ha "action spectrum sensitivity" e kholoanyane, ts'ebetso e arabela haholoanyane ho bolelele boo ba maqhubu.

Sebopeho sa liketso bakeng sa psoriasis se ithutile1,2 ho fumana hore maqhubu a phekolo ka ho fetisisa ke 296 ho 313 nm. Joalokaha ho bontšitsoe ho SEBELETSO B, mabone a tloaelehileng a UVB-Broadband a koahela sebaka sena 'me a sebelisitsoe ka katleho ka lilemo tse fetang 60.

Sebopeho sa liketso bakeng sa "ho chesoa ke letsatsi" ha letlalo la motho, le tsejoang hape e le "erythema", le eona e ithutoa.11 Erythema e laoloa ke maqhubu a tlase (ka tlase ho 300 nm) a mofuta oa UVB. Ka bomalimabe, mabone a tloaelehileng a UVB-Broadband a hlahisa "leseli" le leholo sebakeng sena sa erythemogenic. Li-wavelengths tsena li hlahisa ho chesa 'me li na le molemo o fokolang oa phekolo. Ho feta moo, ho qala ho chesoa ho fokotsa tekanyetso ea UVB3 'me erythema ke ntho e kotsi bakeng sa mofetše oa letlalo. Erythema e boetse e baka ho se phutholohe ha mokuli, e leng se ka 'nang sa nyahamisa bakuli ba bang ho nka kalafo. Sebaka se bohlooho se nang le moriti ka hare SEBELETSO C e fana ka setšoantšo se hlakileng sa litaba tsa erythemogenic tsa UVB-Broadband.

uvbbroadband erythema kutloisiso ea narrowband uvb phototherapy

"Joale ke hobane'ng ha u sa hlahise mohloli o khanyang o hlahisang boholo ba tlhahiso ea oona ho psoriasis action spectrum le ho fokotsa khanya ho erythema action spectrum?"

uvbnarrowband erythema kutloisiso ea narrowband uvb phototherapy

Qetellong ea lilemo tsa bo-1980, Philips Lighting ea Holland e ile ea hlahisa lebone le joalo, le tsejoang e le "TL-01" kapa "UVB Narrowband" lebone. Sebaka se senyane se bohlooho se nang le moriti SEBELETSO D e bontša hore mabone a UVB-Narrowband a na le tlhahiso e fokolang haholo ea erythemogenic (mokhoa oa ho chesoa ke letsatsi) ho feta mabone a tloaelehileng a UVB-Broadband. Sena se bolela hore UVB ea kalafo e eketsehileng e ka fanoa pele erythema e hlaha, 'me kaha erythema ke ntho e kotsi bakeng sa mofetše oa letlalo, mabone ana a macha ha aa lokela ho ba le kankere bakeng sa liphello tse tšoanang tsa phekolo.4,5,6,7. Ho feta moo, 'me e bohlokoa katlehong e bonoang ke lehae la UVB-Narrowband phototherapy, ho ba bonolo haholo hore lefu lena le laolehe ntle le ho fihla moeling oa erythemogenic.9,10, e neng e lula e le bothata ka liphekolo tsa UVB-Broadband. Hoa thahasellisa ho hlokomela hore tlhōrō ea sekhahla sa UVB-Narrowband se phahame ka makhetlo a leshome ho feta UVB-Broadband curve, kahoo mohloli oa lebitso "Narrowband".

Liphuputso tsa morao-rao li netefalitse liphuputso tsena hape li fumane hore UVB-Narrowband e na le liketsahalo tse fokolang tsa ho chesa le linako tse telele tsa ho tšoareloa ho feta UVB-Broadband. Ha e bapisoa le PUVA (Psoralen + UVA-1 light), UVB-Narrowband e na le litla-morao tse fokolang haholo 'me e e nketse sebaka hangata.8.

Phoso e 'ngoe ea UVB-Narrowband ke hore, ka lebaka la hore tekanyetso e phahameng e lekantsoe ke ho qala ha erythema e nyane, mme UVB-Narrowband ha e na erythemogenic ho feta UVB-Broadband, ho hlokahala nako e telele ea kalafo. Sena se ka lefshoa ka ho eketsa palo ea bulbs sesebelisoa4,5,6,7. Ka mohlala, ho itšetlehile ka phototherapy ea lehae ea Solarc ka mor'a ho latela thekiso ea UVB-Broadband, 4-bulb 1740UVB e fana ka linako tse utloahalang tsa phekolo; athe bakeng sa UVB-Narrowband, 8-bulb 1780UVB-NB ke khetho e tloaelehileng. Karolelano ea khopolo-taba ea matla a erythemogenic a UVB-Broadband ho UVB-Narrowband e maemong a 4:1 ho isa ho 5:1.

Mafu a mang a kang vitiligo, eczema, mycosis fungoides (CTCL), le a mang a mangata a boetse a phekoloa ka katleho ka UVB-Narrowband, ka kakaretso ka mabaka a hlalositsoeng ka holimo bakeng sa psoriasis.

Molemo o mong o khahlisang oa UVB-Narrowband ke hore e kanna ea ba mofuta o motle ka ho fetisisa oa lebone la fluorescent bakeng sa ho etsa Vithamine D (SETLHOPHA E) letlalong la motho, bakeng sa ho sebelisoa ho e-na le khanya ea letsatsi ea tlhaho (e akarelletsang UVA e kotsi), kapa bakeng sa ba sa khoneng ho monya vithamine D (matlapa) e lekaneng ea molomo ka lebaka la mathata a maleng. Taba ea vithamine D e se e fumane tlhokomelo e kholo ea mecha ea litaba morao tjena, 'me ka mabaka a utloahalang. Vithamine D ke ea bohlokoa bakeng sa bophelo bo botle ba batho, leha ho le joalo batho ba bangata ba haelloa ke lintho, haholo-holo ba lulang libakeng tse phahameng, tse hōle le equator ea lefatše. Ho na le bopaki bo ntseng bo eketseha ba hore Vithamine D e sireletsa khahlanong le nts'etsopele ea maloetse a mangata a sa foleng, ho kopanyelletsa le kankere (matsoele, colorectal, prostate), lefu la pelo, multiple sclerosis, osteomalacia, osteoporosis, mofuta oa 1 lefu la tsoekere, lefu la ramatiki, khatello ea kelello le khatello ea maikutlo. Ho fumana lintlha tse ling, ka kopo etela maqephe ana a tepo: Vitamin D Phototherapy FAQ & Mabone a vithamine D.

uvbnarrowband vitamind kutloisiso narrowband uvb phototherapy

Maikutlo a atileng sechabeng sa dermatology ke hore UVB-Narrowband qetellong e tla nkela UVB-Broadband sebaka e le khetho ea kalafo, haholo bakeng sa phototherapy ea lapeng. Sena se tšehetsoa ka ho hlaka ke mokhoa oa Solarc Systems oa thekiso ea thepa ea lapeng ea phototherapy, 'me thekiso ea lisebelisoa tsa UVB-NB e se e feta thekiso ea UVB-BB ka hoo e ka bang 100:1. Mefuta ea UVB-Narrowband ea Solarc e na le sekoaelo sa "UVB-NB" nomorong ea mohlala, joalo ka 1780UVB-NB. Mefuta ea UVB-Broadband ea Solarc e na le sehokelo sa "UVB" feela, joalo ka 1740UVB.

Solarc Systems e rata ho leboha batho ba molemo ba Philips Lighting ka ho hlahisa mohala oa sehlahisoa sa UVB-Narrowband, le ho thusa ba bangata ba rona lefats'eng ka bophara ho laola mathata a rona a letlalo ka mokhoa o sireletsehileng le ka katleho. Hlokomela: Lipalo tse sebelisitsoeng tokomaneng ena ke litlhaloso tse nolofalitsoeng. Mokokotlo oa UVB-Broadband o nkiloe ho Solarc/SolRx 1740UVB 'me sekhahla sa UVB-Narrowband se tsoa ho Solarc/SolRx 1760UVB‑NB.

Re u khothalletsa ho etsa lipatlisiso ka taba ena ea bohlokoa ho ea pele.

References:

1 PARRISH JA, JAENICKE KF (1981) Action Spectrum bakeng sa phototherapy ea psoriasis. J Ho kenya Dermatol. 76 359
2 FISCHER T, ALSINS J, BERNE B (1984) Ultraviolet-action spectrum le tlhahlobo ea mabone a ultraviolet bakeng sa pholiso ea psoriasis. Int. J. Dermatol. 23 633
3 BOER I, SCHOTHORST AA, SUURMOND D (1980) UVB phototherapy ea psoriasis. Dermatological 161 250
4 VAN WEELDEN H, BAART DE LA FAILLE H, YOUNG E, VAN DER LEUN JC, (1988) Tsoelo-pele e ncha ea UVB phototherapy ea psoriasis. British Journal of Dermatology 119
5 KARVONEN J, KOKKONEN E, RUOTSALAINEN E (1989) 311nm UVB mabone a phekolo ea psoriasis ka mokhoa oa Ingram. Acta Derm Venereol (Stockh) 69
6 JOHNSON B, GREEN C, LAKSHMIPATHI T, FERGUSON J (1988) Ultraviolet radiation phototherapy bakeng sa psoriasis. Tšebeliso ea lebone le lecha le moqotetsane la UVB la lebone la fluorescent. Proc. Eura ea bo-2. Photobiol. Congr., Padua, Italy
7 GREEN C, FERGUSON J, LAKSHMIPATHI T, JOHNSON B 311 UV phototherapy - Phekolo e sebetsang bakeng sa psoriasis. Lefapha la Dermatology, Univesithi ea Dundee
8 TANEW A, RADAKOVIC-FIJAN S, SC
HEMPER M, HONIGSMANN H (1999) Narrowband UV-B phototherapy vs photochemotherapy kalafong ea plaque-type psoriasis. Arch Dermatol 1999; 135:519-524
9 WALTERS I, (1999) Suberythematogenic narrow-band UVB e sebetsa hantle ho feta UVB e tloaelehileng kalafong ea psoriasis vulgaris. J Am Acad Dermatol 1999; 40:893-900
10 HAYKAL KA, DESGROSEILLIERS JP (2006) Na Liuniti tsa Lehae tsa Narrow-band Ultraviolet B ke Khetho e ka khonehang bakeng sa Phekolo e Tsoelang Pele kapa ea Tlhokomelo ea Mafu a Letlalo a Phokotso? Journal of Cutaneous Medicine & Surgery, Buka ea 10, Khatiso ea 5: 234-240
11 Erythema reference action spectrum le standard erythema dose ISO-17166:1999(E) | CIE S 007/E-1998
12 Action Spectrum bakeng sa Tlhahiso ea Previtamin D3 ka Letlalo la Motho CIE 174: 2006